Method of improving cognitive functions in individuals with down syndrome and/or alzheimer's disease description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20100298431, Method of improving cognitive functions in individuals with down syndrome and/or alzheimer's disease.

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CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to provisional application, U.S. Ser. No. 61/213,173, filed on May 14, 2009.

FIELD OF THE INVENTION

The present invention provides a method of improving cognitive functions in individuals with Down syndrome and/or Alzheimer\'s Disease and/or Parkinson\'s Disease or other diseases or conditions that would result in degeneration of locus coerulus (LC).

DESCRIPTION OF THE BACKGROUND

Down syndrome (DS) is a complex genetic disorder caused by a third copy of chromosome 21 resulting in triplication of −300 genes. It is the most common source of congenital anomalies with a prevalence of 1 per 733 live births in the US, resulting in the birth each year of 5,000 affected infants. Among several abnormalities occurring with DS, intellectual deficiencies that affect the quality of life for both children and adults is a primary concern. Understanding the neurobiological basis of failed cognition in DS is, thus, a high priority with the hope that deciphering pathogenesis will lead to effective therapies...........

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